How to kill alien salazar in like
[Submitted by: igotallinfo ]
Before you go into the room at the top of the tower where ashley was taken make sure to buy a rocket launcher and also a broken butterfly if you dont have one allready and when you go in there just shoot the aliens eye until he goes down and salazar comes out of that:whole..thing and then shoot him with the rocket launcher//i seriously shot the guys eye like 3 times and then killed salazar in like 8 seconds it was crazy

Chicago Typewriter Weapon
Beat Operation Ada, and the "Chicago Typewriter", a Thompson with 10.0 firepower, infinite ammo, no reload, and the fire rate of a maxed out TMP, becomes available at the merchant.

S.T.A.R.S. Uniform
To Unlock The S.T.A.R.S. Uniform You Must Complete The Game On Normal Or Hard Mode.

Snake in the Box
When you destroy the wooden crates sometimes a snake will jump out and bite you. OUCH! If you keep slashing with your knife when the box breaks you can kill the snake and receive a healing egg.

Assignment Ada Mini-game
Beat the game to unlock the mini game.

Rocket Launcher
To unlock the Rocket Launcher Special you must beat the game on Normal and you get a chance too buy the Matilda and the Infinite Launcher. The Matilda is $70,000 and the Infinite Launcher is $1000000.

Thompson (Chicago Typewriter)
Win Operation Ada and the "Chicago Typewriter". Doing so will make available a Thompson at the merchant. This Thompson comes with 10.0 firepower, infinite ammo, no reload, and the fire rate of a maxed out TMP. Beating Operation Ada will only unlock the Chicago Typewriter for Ada in her Separate Ways mission and not any other mode. To unlock the Thompson for Leon's mission you need to beat the Ada's Separate Ways mission.

Submitted by Luksifer

Correction by Chuck0Latte (chuck.moote)

Special Costume 2
[Submitted by: CheatMasters ]
You will need to clear the game a second time (you must load the once-cleared game file) on Normal or Professional difficulty (the costumes are stored separately with each difficulty) for special costume set 2.

Leon can do hat tricks. You may have to have the Chicago Typewriter weapon equipped to perform these funny actions:

Hat Adjust: Hold the ready weapon button (B) and perform the reload weapon gesture with the Wii Remote. Since this weapon has unlimited ammo Leon will just adjust his hat.

Hat Toss: Hold the ready weapon button (B) and perform a quick DOWN then UP motion with the Wii Remote. This is the more comical of the two gestures, but doesn’t always work. you may perform the Hat Adjust move more often.

Ashley will unlock a metal suit of armor that protects her from any damage and prevents enemies from carrying her away. Now you can leave Ashley were ever you desire in the current area without worrying about her being child-napped.

There is one part when Leon must snipe drivers on a tunnel digging machine that threatens to crush Ashley; you can let the machine clip though Ashley, the zombies die, and the gate unlocks for armored Ashley to escape.

Punisher Weapon
Shoot 10 of the 15 blue medallions in the game. There is a map you can find in the farm area just beyond the first village with the bell tower. After getting the map, the locations of all 15 medallions will show on your map. When you've destroyed at least 10, talk to the merchant for a free gun.

Broken Butterfly Weapon
In the hall south of the hedge maze there is a locked door. Return to that area with Ashley, piggy back with her and she will unlock the door. This reveals the broken butterfly.

Harvest Eggs for $$$ Peseta
Where ever you see chickens running around wait a bit and they’ll lay an egg. Once you collect a couple eggs leave the area and come back. The chickens will lay more eggs each time.
One of the best locations is the area where you first see the Blue Medallions and receive the memo from the merchant. That area has 3 cows that are in the pen and 2 in the barn. There are 6 chickens running around in both pens. This one can definitely take some time, but the chickens have all day and seem to lay an endless number of eggs.
White Egg = 300 peseta
Brown Egg = 600 peseta
Golden Egg = 3000 peseta

Clean Treasures
Here is the hint: before shooting a treasure into the dirty well, blast the piece of wood propping up the cover to keep the item clean. This is the only way that Ada will pick up those treasures and it will also ensure a higher value when selling to the merchant.
*** You can accidentally raise the lid once more if you close it by pressing Action. You cannot clost the well once you do so.

More Money : Beerstein & Elegant Mask
When you find these items do not sell them right away. You can increase the value of the items with gems.

Fast Aiming
There is a faster way to center your gun when aiming up or down. Simply tap the L1 button (takes out your knife) and you will quickly aim straight ahead.

Maximize Leons Lifebar Tips
This trick incurs many continues, which have no affect on the game's ending. At the first El Gigante fight, there is a Yellow Herb in the boss arena. Take this item and combine it with any of the Green Herbs in the same room and use it. This increases Leon's lifebar slightly. Now let the boss kill Leon. Since the boss' room is at a map transition (the green OPEN command is a dead giveaway), this lets you continue right at the boss fight but with Leon's life increase from your previous attempt. Repeating this process will increase Leon's lifebar to maximum prematurely. Extra Yellow Herbs found later can be given to Ashley, or sold to the merchant for money.

Do not Reload Your Gun before upgrade
Whenever you upgrade your gun's capacity it fills the weapon with ammo. So don't reload before you buy the upgrade. This works great with weapons that have very little ammo (such as the magnum revolver 'Broken Butterfly'); after you use up the gun's magazine, simply look for the merchant and upgrade the ammo capacity.

[Double] Broken Butterfly Ammo
Buy the broken butterfly before you find it, you can hold twice the ammo. The shopkeeper will not sell you this gun if you already have it.

Unlockable PRL412
Do you know what it is? The P.R.L 412 Weapon is a laser gun with unlimited ammo. You can se it shown briefly in the attract mode if you leave your game running on the start menu. The PRL412 is used by charging up and then releasing bolts of energy into one or many enemies or objects (boxes and barrels can destroyed). Just ready your weapon (hold B) then hold down the A button until the weapon charges to your desired level. Note that the PRL412 only destroys the not-zombies with parasites in them and does not affect enemies without parasites.

Unlock Matilda Weapon
Unlock the Matilda handgun (which fires 3 round bursts) by clearing the game.

Mercenaries Mini-Game
Beat the game to unlock the mercenaries mini game.