Remote Boss Killer
Description: If you decide to play as an alchemist with chain lightning, you can kill most bosses without even entering their room.
How to: When a boss' room is not attached to the room you are currently in, but is diagonally opposite from the room you're in, you can move towards the boss icon and cause the boss' name to appear on the screen. Unleashing chain lightning towards the boss at this point will damage the boss and your whack job will be made that much easier.

[Glitch] Lost Some Weight
How to: Enchant a piece of armor that gives strength to you or get a piece of jewlery that does the same thing. When you come across items you do not have enough encumbrence for, equip the strength accessory or armor, take the item, then swap the strength-augmenting accessory for your original equipment.

Duplicate Items
How to: Connect to a multiplayer game and have one player give all items to the second player. The player that gave away the items then restarts the game without saving. When that same player starts the game again, all of the items will still be in player one's inventory, and still in player two's inventory.

Save 101
Description: An easy way to save your important items and progress.
How to: Just before you die, hit start and "Recall to Aven," then buy health potions or wait untill your HP is full, or after you die, hit start, Exit, and Save game. While you have to reload with the second choice, at least you get to keep your stuff (it saves to a few seconds before you die). Neither of these work while a boss's name is visible at the bottom of the screen.

Archery Rules
If you work to become a knight or druid, you can plow your level-up points towards archery. High archery levels will let you kill most enemies from afar with bows and arrows and make things slightly easier.